Journal article
Brain network changes after the first seizure: An insight into medication response?
M Pedersen, H Pardoe, R Mito, M Sethi, DN Vaughan, PW Carney, GD Jackson
Brain Communications | OXFORD UNIV PRESS | Published : 2024
Abstract
After a first epileptic seizure, anti-seizure medications (ASMs) can change the likelihood of having a further event. This prospective study aimed to quantify brain network changes associated with taking ASM monotherapy. We applied graph theoretical network analysis to longitudinal resting-state functional MRI (fMRI) data from 28 participants who had recently experienced their first seizure. Participants were imaged before and during long-Term ASM therapy, with a mean inter-scan interval of 6.9 months. After commencing ASM, we observed an increase in the clustering coefficient and a decrease in network path length. Brain changes after ASM treatment were most prominent in the superior frontop..
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Awarded by State Government of Victoria
Funding Acknowledgements
We thank Magdalena Kowalczyk, Donna Parker and Mira Semmelroch for recruiting participants for this study. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (#628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular, the funding from the Operational Infrastructure Support Grant. We also acknowledge the facilities and the scientific and technical assistance of the National Imaging Facility (NIF) at the Florey node and The Victorian Biomedical Imaging Capability (VBIC). M.P. acknowledges support from the Health Research Council, New Zealand.